Compound name
CQ211
Protein family
Protein Kinase
Target name
RIOK2
Affinity biochemical (nM)
6.1
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002914a
SMILES
O=C1C2=C(C3=CC(C4=CC=C(N=C4)OC)=CC=C3N1)N(N=N2)C5=CC=C(C(C(F)(F)F)=C5)N6CCNCC6
InChIKey
RGHLRMNPUGUZEY-UHFFFAOYSA-N
NCBI gene ID
55781
UniProt ID
Q9BVS4
Synonyms
FLJ11159
Mode of action
Inhibitor
Affinity biochemical definition
Kd
Affinity biochemical assay type
Competition binding assay (DiscoverX)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/35584513/
Affinity biochemical relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
468
Selectivity remarks
Screened at 1 µM, closest targets as % of control: FLT3 (ITD, D835V, 4%), FLT3 (ITD, F691L, 3.6%), RIOK1 (100%), RIOK2 (0%), RIOK3 (87%), full screening data are available as supporting information;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/35584513/
Selectivity Number of Off-targets
1