Compound name
TAK1/MAP4K2 inhibitor 1
Protein family
Protein Kinase
Target name
FES
Affinity biochemical (nM)
69.7
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002999a
SMILES
CC(N1)=CC2=C1N=CN=C2OC3=C(C)C=CC(C(NC4=CC=C(CN5CCN(CC)CC5)C(C(F)(F)F)=C4)=O)=C3
InChIKey
RWNAOXLCVXJMGM-UHFFFAOYSA-N
NCBI gene ID
2242
UniProt ID
P07332
Synonyms
FPS
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/25075558/
Affinity biochemical relation
=
Selectivity platform
KiNative profiling (Proteomics)
Selectivity platform number of targets
>200
Selectivity remarks
Screened at 1 µM, using HUH7 cell lysate, closest target as % of inhibition: FER (82.7%), https://pubmed.ncbi.nlm.nih.gov/25075558/;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/25075558/
Selectivity Number of Off-targets
0