Compound name
TAK1-IN-2
Protein family
Protein Kinase
Target name
MAP3K7
Affinity biochemical (nM)
2
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0003000a
SMILES
O=C(C1=CC2=C(CN(C(C3=NC(C(N(CC4=CC=CC=C4OC(F)F)[C@H](C)C(NC)=O)=O)=CN3)=O)C2)C=C1)N
InChIKey
QEAYKBGEHPZBIL-CQSZACIVSA-N
NCBI gene ID
6885
UniProt ID
O43318
Synonyms
MEKK7
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
LanthaScreen assay (10 µM ATP)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/33859795/
Affinity biochemical relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
468
Selectivity remarks
Screened at 1 µM, closest targets as % of control: CSNK2A1 (25%), CSNK2A2 (7.3%), LRRK2 (45%), PIK3CD (32%), PIK3CG(37%), PIP5K1C (7.3%), MAP3K7 (0.85%), full screening data available as supporting information,https://pubmed.ncbi.nlm.nih.gov/33859795/;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/33859795/
Selectivity Number of Off-targets
2