Compound name
XST-14
Protein family
Protein Kinase
Target name
ULK1
Affinity biochemical (nM)
26.6
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0003008a
SMILES
O=C(OC)C1=CC2=C(OC(C)C)C=C(OC(C)C)C=C2N1
InChIKey
ZNFMBFABCSHXPM-UHFFFAOYSA-N
NCBI gene ID
8408
UniProt ID
O75385
Synonyms
ATG1, ATG1A
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
ADP-Glo assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/31986961/
Affinity biochemical relation
=
Selectivity platform
Kinase panel (SelectScreen Kinase Profiling Services)
Selectivity platform number of targets
403
Selectivity remarks
Screened at 5 µM, closest targets >75% inhibition: MAP2K1, MAPK14, TGFBR2, ACVR1, CAMK2A, details an targets are not listed in the paper;
In-vitro potency (enzymatic assay): IC50(MAP2K1) = 721.8 nM, https://pubmed.ncbi.nlm.nih.gov/31986961/;
In-vitro potency (enzymatic assay): IC50(MAPK14) = 283.9 nM, https://pubmed.ncbi.nlm.nih.gov/31986961/;
In-vitro potency (enzymatic assay): IC50(TGFBR2) = 809.3 nM, https://pubmed.ncbi.nlm.nih.gov/31986961/;
In-vitro potency (enzymatic assay): IC50(ACVR1) = 183.8 nM, https://pubmed.ncbi.nlm.nih.gov/31986961/;
In-vitro potency (enzymatic assay): IC50(MAP2K1) = 721.8 nM, https://pubmed.ncbi.nlm.nih.gov/31986961/;
In-vitro potency (enzymatic assay): IC50(MAPK14) = 283.9 nM, https://pubmed.ncbi.nlm.nih.gov/31986961/;
In-vitro potency (enzymatic assay): IC50(TGFBR2) = 809.3 nM, https://pubmed.ncbi.nlm.nih.gov/31986961/;
In-vitro potency (enzymatic assay): IC50(ACVR1) = 183.8 nM, https://pubmed.ncbi.nlm.nih.gov/31986961/;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/31986961/
Selectivity Number of Off-targets
5