Compound name
JNJ-78732576
Protein family
Apoptosis regulator
Target name
MCL1
Affinity biochemical (nM)
115
Affinity on-target cellular (nM)
30000
CG-Set
Other targets set
Recommended Concentration
10 µM
Compound EUbOPEN ID
EUB0003044a
SMILES
CC1=C(C(O)=O)N(CCCOC2=CC(CCC3=CC(CSCC4=C5C(C)=NN4CCOCCOC)=NN3C)=CC6=C2C=C(Cl)C(F)=C6)C7=C1C5=C(Cl)C=C7
InChIKey
NQKQXMWUXJEWJR-UHFFFAOYSA-N
NCBI gene ID
4170
UniProt ID
Q07820
Synonyms
BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
Mode of action
Negative control for JNJ-4355
Affinity biochemical definition
Ki
Affinity biochemical assay type
HTRF assay
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-4355
Affinity biochemical relation
=
Affinity on-target cellular definition
AC50
Affinity on-target cellular assay type
MOLP-8 Caspase Glo assay (using human MOLP8 cells)
Affinity on-target cellular source knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-4355
Affinity on-target cellular relation
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