Compound name
JP3000
Protein family
Nuclear Receptors
Target name
NR2B2
Affinity on-target cellular (nM)
1.4
CG-Set
Nuclear Receptor set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0003045a
SMILES
OC(C(C1)C1C(O2)=NC(C3=CC=CC=C3)=C2C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)=O
InChIKey
CRLZRGXSDBAEFD-UHFFFAOYSA-N
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Gal4 reporter gene assay
Affinity on-target cellular source knowledge
https://doi.org/10.1021/acs.jmedchem.3c01435
Affinity on-target cellular relation
0
Selectivity remarks
Screened at 1 µM against NR1A1, NR1B1, NR1C1, NR1C2, NR1C3, NR1D1, NR1F3, NR1H3, NR1H4, NR1I1, NR1I3, NR2A1, NR2B1, NR2C1, NR2C2, NR2E1, NR2E3, NR4A1, NR5A1 and VP16 in a Gal4 hybrid reporter gene assay (HEK293T cells were cotransfected with pFR-Luc reporter, pRL-SV40 control reporter and pFA-CMV
Selectivity Source Knowledge
https://doi.org/10.1021/acsptsci.4c00719