Compound name
HX531
Protein family
Nuclear Receptors
Target name
NR2B3
Affinity on-target cellular (nM)
n.d.
CG-Set
Nuclear Receptor set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0003074a
SMILES
CC1(C2=C(C(C)(CC1)C)C=C(C3=C2)N(C4=C(N=C3C5=CC=C(C=C5)C(O)=O)C=C([N+]([O-])=O)C=C4)C)C
InChIKey
SXKPGYKPQPYJER-UHFFFAOYSA-N
Mode of action
Antagonist
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1248/cpb.47.1778
Affinity on-target cellular relation
0
Selectivity remarks
Screened at 1 µM against NR1A1, NR1B1, NR1C1, NR1C2, NR1C3, NR1D1, NR1F3, NR1H3, NR1H4, NR1I1, NR1I3, NR2A1, NR2B1, NR2C1, NR2C2, NR2E1, NR2E3, NR4A1, NR5A1 and VP16 in a Gal4 hybrid reporter gene assay (HEK293T cells were cotransfected with pFR-Luc reporter, pRL-SV40 control reporter and pFA-CMV
Selectivity Source Knowledge
https://doi.org/10.1021/acsptsci.4c00719
Selectivity Number of Off-targets
1