Compound name
Photoregulin 1
Protein family
Nuclear Receptors
Target name
NR2E3
Affinity on-target cellular (nM)
250
CG-Set
Nuclear Receptor set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0003075a
SMILES
O=C(NC1=CC(C)=CC(C)=C1)CCC2=NC3=C(C4=C(CCCC4)S3)C(N2)=O
InChIKey
HGXMLGSUGNEINU-UHFFFAOYSA-N
NCBI gene ID
10002
UniProt ID
Q9Y5X4
Synonyms
PNR, rd7, RP37
Mode of action
Inverse Agonist
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1167/iovs.16-20177
Affinity on-target cellular relation
0
Selectivity remarks
Screened at 1 µM against NR1A1, NR1B1, NR1C1, NR1C2, NR1C3, NR1D1, NR1F3, NR1H3, NR1H4, NR1I1, NR1I3, NR2A1, NR2B1, NR2C1, NR2C2, NR2E1, NR2E3, NR4A1, NR5A1 and VP16 in a Gal4 hybrid reporter gene assay (HEK293T cells were cotransfected with pFR-Luc reporter, pRL-SV40 control reporter and pFA-CMV
Selectivity Source Knowledge
https://doi.org/10.1021/acsptsci.4c00719
Selectivity Number of Off-targets
1