Compound name
Valerenic acid
Protein family
Nuclear Receptors
Target name
NR2B2
Affinity on-target cellular (nM)
5200
CG-Set
Nuclear Receptor set
Recommended Concentration
10 µM
Compound EUbOPEN ID
EUB0003324a
SMILES
CC1=C2[C@@H](CC[C@H]([C@]2(CC1)[H])C)/C=C(C)/C(O)=O
InChIKey
FEBNTWHYQKGEIQ-SUKRRCERSA-N
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Gal4 reporter gene assay
Affinity on-target cellular source knowledge
https://doi.org/10.1021/acs.jmedchem.8b00494
Affinity on-target cellular relation
0
Selectivity remarks
Screened at 10 µM against NR1A1, NR1B1, NR1C1, NR1C2, NR1C3, NR1D1, NR1F3, NR1H3, NR1H4, NR1I1, NR1I3, NR2A1, NR2B1, NR2C1, NR2C2, NR2E1, NR2E3, NR4A1, NR5A1 and VP16 in a Gal4 hybrid reporter gene assay (HEK293T cells were cotransfected with pFR-Luc reporter, pRL-SV40 control reporter and pFA-CMV
Selectivity Source Knowledge
https://doi.org/10.1021/acsptsci.4c00719