Compound name
Biliverdine
Protein family
Nuclear Receptors
Target name
NR2E3
Affinity on-target cellular (nM)
5
CG-Set
Nuclear Receptor set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0003329a
SMILES
CC1=C(/C(N/C1=C/C2=NC(C(C=C)=C2C)=O)=C/C3=C(C(C)=C(N3)/C=C4C(C=C)=C(C(N\4)=O)C)CCC(O)=O)CCC(O)=O
InChIKey
RCNSAJSGRJSBKK-LFKMQHSASA-N
NCBI gene ID
10002
UniProt ID
Q9Y5X4
Synonyms
PNR, rd7, RP37
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Gal4 reporter gene assay
Affinity on-target cellular source knowledge
https://doi.org/10.1038/s41598-022-11502-3
Affinity on-target cellular relation
0
Selectivity remarks
Screened at 1 µM against NR1A1, NR1B1, NR1C1, NR1C2, NR1C3, NR1D1, NR1F3, NR1H3, NR1H4, NR1I1, NR1I3, NR2A1, NR2B1, NR2C1, NR2C2, NR2E1, NR2E3, NR4A1, NR5A1 and VP16 in a Gal4 hybrid reporter gene assay (HEK293T cells were cotransfected with pFR-Luc reporter, pRL-SV40 control reporter and pFA-CMV
Selectivity Source Knowledge
https://doi.org/10.1021/acsptsci.4c00719