Compound name
CI-1040
Protein family
Protein Kinase
Target name
MAP2K1
Affinity biochemical (nM)
120
Affinity on-target cellular (nM)
46
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000599a
SMILES
C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl
InChIKey
GFMMXOIFOQCCGU-UHFFFAOYSA-N
NCBI gene ID
5604
UniProt ID
Q02750
Synonyms
MEK1, MAPKK1
Mode of action
Inhibitor
Affinity biochemical definition
Kd
Affinity biochemical assay type
Competition binding assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1038/nbt.1990
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
ELISA (mouse colon 26 carcinoma cells)
Affinity on-target cellular relation
=
Selectivity platform
Competition binding assay by Davis et.al., literature
Selectivity platform number of targets
442
Selectivity remarks
S(Kd < 300 nM) =0.0026, S(Kd < 3µM) = 0.0078
Selectivity Source Knowledge
https://doi.org/10.1038/nbt.1990
Selectivity Number of Off-targets
0