Compound name
BAY-826
Protein family
Protein Kinase
Target name
DDR1
Affinity biochemical (nM)
0.4
Affinity on-target cellular (nM)
0.9
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000713a
SMILES
N#CC1=CC(S(F)(F)(F)(F)F)=CC(C(NC2=C(C)C=C(C)C(N3C=CN(C3=C4)N=C4C5=CN=CC=C5)=C2)=O)=C1
InChIKey
MPASHPJAIUOWCK-UHFFFAOYSA-N
NCBI gene ID
780
UniProt ID
Q08345
Synonyms
RTK6, CD167
Mode of action
Inhibitor
Negative control
BAY-309
Affinity biochemical definition
Kd
Affinity biochemical assay type
KdELECT (DiscoverX)
Affinity Biochemical Source Knowledge
https://doi.org/10.1111/jnc.13877
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY-826
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular relation
=
Selectivity platform
Kinome Scan (DiscoverX)
Selectivity platform number of targets
453
Selectivity remarks
Screened at 100 nM, closest targets: Kd(STK10) = 5.9 nM, Ki(EPHB6) = 25 nM, Ki(ABL-1, non-phosphorylated) = 38 nM, Ki(LYN) = 40 nM; Cellular selectivity, of closest targets in HEK293T cells (NanoBRET assay): IC50(STK10) = 210 ± 97 nM (n= 2), IC50(EPHB6) = 3.9 ± 0.3 µM (n= 2), IC50(LYN) = 8.2 ± 0.86 µM (n= 2); Screened against 45 GPCR targets (PDSP screen) at 10 µM, closest targets: Ki(OPRK1) = 124.61 nM, Ki(GABA/PBR) = 217.26 nM, Ki(TMEM97) = 983.68 nM, Ki(ADRB3) = 7099.67 nM
Selectivity Source Knowledge
https://doi.org/10.1111/jnc.13877
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY-826
Selectivity Number of Off-targets
0