Compound name
(-)-JQ1
Protein family
Bromodomain
Target name
BRDT@BD2
Affinity biochemical (nM)
Negative Control
CG-Set
Epigenetic set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000200b
SMILES
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2
InChIKey
DNVXATUJJDPFDM-QGZVFWFLSA-N
NCBI gene ID
676
UniProt ID
Q58F21
Synonyms
BRD6, CT9
Mode of action
Negative control for (+)-JQ1
Affinity Biochemical Source Knowledge
https://www.thesgc.org/chemical-probes/JQ1
Selectivity platform
Bromodomain panel (DSF assays, literature)
Selectivity platform number of targets
37
Selectivity remarks
Screened at 10 µM in DSF-assay, closest target: dTm(CREBBP) = 1.18 K;
Selectivity Source Knowledge
https://www.nature.com/articles/nature09504