Colorectal cancer

Colorectal cancer (CRC) remains one of the most frequent neoplasms and is considered the second leading cause of cancer death worldwide. CRC is often detected at advanced stages when tumor cells have already started to spread. Surgery and chemotherapy have improved the prognosis for many CRC patients. However, frequent relapse in patients with metastatic disease still results in a poor prognosis with a 5 year survival rate of less than 20%, highlighting an urgent need for alternative treatment approaches. Because CRC is characterized by prominent genetic and phenotypic heterogeneity between patients the identification of actionable drivers for personalized therapy remains challenging.