1. Chemogenomics
2. CFTR

CFTR

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

1080

1884

P13569

CFTR_HUMAN

CF transmembrane conductance regulator

ABC transporter

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000264b

A-1596584

COc1ccc2c(c1)O[C@H](C[C@H]2NC(C1(CC1)c1ccc2c(c1)OC(O2)(F)F)=O)c1ccc(c(c1)OC)OC

KDOQEEMQPHIANX-NFBKMPQASA-N

Neg Ctrl (A-1596586)

CFTR

Yes

Yes

No

Yes

EUB0000544a

A-1596586

COc1ccc2c(c1)O[C@@H](C[C@@H]2NC(C1(CC1)c1ccc2c(c1)OC(O2)(F)F)=O)c1ccc(c(c1)OC)OC

KDOQEEMQPHIANX-REWPJTCUSA-N

corrector

CFTR

Yes

Yes

No

Yes