1. Chemogenomics
2. EDNRA

EDNRA

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

1909

3179

P25101

EDNRA_HUMAN

endothelin receptor type A

GPCR

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000289bCl

A-545

CCCCN(C(CN1C[C@@H](C2=CC(OC)=C3OCOC3=C2)[C@H](C(O)=O)[C@H]1CC(C)(CCC)C)=O)CCCC.Cl

KMKKFZCVBRAWNX-GSAMTNRBSA-N

Neg Ctrl (ABT-546)

EDNRA

Yes

Yes

No

Yes

EUB0000348aPTSA

ABT-546

COC1=CC([C@@H]2[C@H]([C@@H](N(C2)CC(N(CCCC)CCCC)=O)CC(C)(CCC)C)C(O)=O)=CC3=C1OCO3.CC4=CC=C(S(=O)(O)=O)C=C4

AADJQCRYJYCVDO-KQQHTNMISA-N

antagonist

EDNRA

Yes

Yes

No

Yes

EUB0000379a

FR 139317

CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](CC1=CN(C)C2=CC=CC=C12)C(=O)N[C@H](CC1=NC=CC=C1)C(O)=O

LIOKMIQQPDDTNO-UPRLRBBYSA-N

Antagonist

EDNRA

Yes

Yes

No

Yes

EUB0000384a

CI 1020

COC1=CC=C(C=C1)C1(O)OC(=O)C(=C1CC1=CC(OC)=C(OC)C(OC)=C1)C1=CC=C2OCOC2=C1

PWIPORDFWDZCJG-UHFFFAOYSA-N

Antagonist

EDNRA

Yes

Yes

No

Yes

EUB0000395a

A 127722

CCCCN(CCCC)C(=O)CN1C[C@H]([C@@H]([C@H]1C1=CC=C(OC)C=C1)C(O)=O)C1=CC2=C(OCO2)C=C1

MOTJMGVDPWRKOC-MXSCXNJPSA-N

Antagonist

EDNRA

Yes

Yes

No

Yes

EUB0000496a

MACITENTAN

CCCNS(=O)(=O)NC1=NC=NC(OCCOC2=NC=C(Br)C=N2)=C1C1=CC=C(Br)C=C1

JGCMEBMXRHSZKX-UHFFFAOYSA-N

Antagonist

EDNRA

Yes

Yes

No

Yes