1. Chemogenomics
2. EDNRB

EDNRB

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

1910

3180

P24530

EDNRB_HUMAN

endothelin receptor type B

GPCR

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000339a

A-1806262

CCCOC1=CC=C([C@@H]2[C@H]([C@H](C3=CC=C4C(OCO4)=C3)CN2CC(NC5=C(C=CC=C5CC)CC)=O)C(O)=O)C=C1

LQEHCKYYIXQEBM-WXALXNGTSA-N

Neg Ctrl (A-192621)

EDNRB

Yes

Yes

No

Yes

EUB0000350a

A-192621

CCCOC1=CC=C([C@H]2[C@@H]([C@@H](C3=CC(OCO4)=C4C=C3)CN2CC(NC5=C(C=CC=C5CC)CC)=O)C(O)=O)C=C1

LQEHCKYYIXQEBM-FUKIBTTHSA-N

antagonist

EDNRB

Yes

Yes

No

Yes

EUB0000399a

IRL 2500

CN([C@H](CC1=CC=C(C=C1)C1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O)C(=O)C1=CC(C)=CC(C)=C1

UZDORQWMYRRLQV-JHOUSYSJSA-N

Antagonist

EDNRB

Yes

Yes

No

Yes