1. Chemogenomics
2. PIK3CD

PIK3CD

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

5293

8977

O00329

PK3CD_HUMAN

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

lipid-kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000049b

Pictilisib (GDC-0941)

CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1

LHNIIDJUOCFXAP-UHFFFAOYSA-N

PIK3CA

,

PIK3CB

,

PIK3CD

,

PIK3CG

Yes

Yes

No

Yes

EUB0000656a

ZSTK474

FC(F)C1=NC(C=CC=C2)=C2N1C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3

HGVNLRPZOWWDKD-UHFFFAOYSA-N

PIK3CA

,

PIK3CB

,

PIK3CD

,

PIK3CG

Yes

Yes

No

Yes

EUB0000658a

PI-103

Oc1cccc(c1)c1nc(N2CCOCC2)c2oc3ncccc3c2n1

TUVCWJQQGGETHL-UHFFFAOYSA-N

PIK3C2B

,

PIK3CA

,

PIK3CB

,

PIK3CD

,

PIK3CG

,

PRKDC

Yes

Yes

Yes

Yes

EUB0000685a

Taselisib

CC1=NN(C(C)C)C(C2=CN(CCO3)C(C4=C3C=C(C5=CN(C(C)(C)C(N)=O)N=C5)C=C4)=N2)=N1

BEUQXVWXFDOSAQ-UHFFFAOYSA-N

PIK3CA

,

PIK3CD

,

PIK3CG

No

Yes

No

Yes

EUB0000691a

Omipalisib

COC1=C(NS(C2=CC=C(F)C=C2F)(=O)=O)C=C(C3=CC(C(C4=CC=NN=C4)=CC=N5)=C5C=C3)C=N1

CGBJSGAELGCMKE-UHFFFAOYSA-N

PIK3CA

,

PIK3CB

,

PIK3CD

,

PIK3CG

Yes

Yes

Yes

Yes

EUB0000696a

umbralisib

C[C@@H](C1=C(C2=CC(F)=CC=C2)C(C3=CC(F)=CC=C3O1)=O)N4N=C(C5=CC=C(OC(C)C)C(F)=C5)C6=C(N)N=CN=C46

IUVCFHHAEHNCFT-INIZCTEOSA-N

PIK3CD

Yes

Yes

No

Yes

EUB0000876a

CAL-101

FC1=CC=CC(N=C([C@@H](NC2=C(N=CN3)C3=NC=N2)CC)N4C5=CC=CC=C5)=C1C4=O

IFSDAJWBUCMOAH-HNNXBMFYSA-N

PIK3CD

Yes

Yes

No

Yes

EUB0000877a

leniolisib

COC1=NC=C(N2CC(C(N[C@H]3CCN(C(CC)=O)C3)=NC=N4)=C4CC2)C=C1C(F)(F)F

MWKYMZXCGYXLPL-ZDUSSCGKSA-N

PIK3CD

Yes

Yes

No

Yes