1. Chemogenomics
2. ROCK1

ROCK1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

6093

10251

Q13464

ROCK1_HUMAN

Rho-associated protein kinase 1

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000134b

GSK429286A

CC1=C(C(=O)Nc2cc3cn[nH]c3cc2F)C(c2ccc(C(F)(F)F)cc2)CC(=O)N1

OLIIUAHHAZEXEX-UHFFFAOYSA-N

ROCK1

,

ROCK2

Yes

Yes

Yes

Yes

EUB0000594a

GSK269962

O=C(NC1=CC=CC(OC2=NC=C(N=C(C3=NON=C3N)N4CC)C4=C2)=C1)C(C=C5)=CC=C5OCCN6CCOCC6

YOVNFNXUCOWYSG-UHFFFAOYSA-N

ROCK1

,

ROCK2

Yes

Yes

Yes

No

EUB0000606a

CAY10622

NC(C1=CC=C(NC(NCC2=CC(C(NC3=CC(CNCC4)=C4C=C3)=O)=CC=C2)=O)C=C1)=O

SCIFUGGHOXNSJC-UHFFFAOYSA-N

ROCK1

,

ROCK2

Yes

Yes

No

No

EUB0000709a

BAY-4900

CN1C=C(Cl)C2=C1N=CC=C2OC3=C(F)C=C(NC4=NC(N)=NC(Cl)=C4)C=C3F

LQNZFNWBROGUOM-UHFFFAOYSA-N

Neg Ctrl (BAY-549)

ROCK1

,

ROCK2

Yes

Yes

No

Yes

EUB0000716a

BAY-549

Cc1c[nH]c2c1c(ccn2)Oc1c(cc(cc1F)Nc1cc(nc(N)n1)[Cl])F

NRSGWEVTVGZDFC-UHFFFAOYSA-N

ROCK1

,

ROCK2

Yes

Yes

Yes

Yes