1. Chemogenomics
2. SYK

SYK

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

6850

11491

P43405

KSYK_HUMAN

Tyrosine-protein kinase SYK

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000630a

Entospletinib

C1COCCN1C2=CC=C(C=C2)NC3=NC(=CN4C3=NC=C4)C5=CC6=C(C=C5)C=NN6

XSMSNFMDVXXHGJ-UHFFFAOYSA-N

SYK

Yes

Yes

Yes

Yes

EUB0000704a

MRL-SYKi-NC

OC([C@H](C(C)(C)C1)CC[C@]1(O)C2=NC=C(S2)C3=CC(NC4=NC=CC(C)=N4)=CC(C)=C3)=O

OYKPWSZSBLRRPL-HOYKHHGWSA-N

Neg Ctrl (MRL-SYKi)

SYK

Yes

Yes

No

Yes

EUB0000714a

MRL-SYKi

OC([C@H](C(C)(C)C1)CC[C@]1(O)C2=NC=C(S2)C3=CC(NC4=CC=CC(C(F)(F)F)=N4)=C(C)C=C3)=O

HUOXIXBCBFNFKF-VOIUYBSRSA-N

SYK

Yes

Yes

No

Yes