1. Chemogenomics
2. ERBB4

ERBB4

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

2066

3432

Q15303

ERBB4_HUMAN

Receptor tyrosine-protein kinase erbB-4

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000600aCl

Canertinib (dihydrochloride)

C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl

JZZFDCXSFTVOJY-UHFFFAOYSA-N

EGFR

,

ERBB2

,

ERBB4

Yes

Yes

No

Yes

EUB0000616aPTSA

AST-1306 (tosylate)

CC1=CC=C(C=C1)S(=O)(=O)O.C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl

ZMUKJEHWLJBODV-UHFFFAOYSA-N

EGFR

,

ERBB2

,

ERBB4

Yes

Yes

Yes

Yes

EUB0000646a

Zanubrutinib

O=C(C=C)N1CCC([C@]2([H])CCNC3=C(C(N)=O)C(C4=CC=C(OC5=CC=CC=C5)C=C4)=NN32)CC1

RNOAOAWBMHREKO-QFIPXVFZSA-N

BLK

,

BMX

,

BTK

,

ERBB4

,

TXK

No

Yes

No

No

EUB0000664a

PF-299804

O=C(NC1=C(OC)C=C(N=CN=C2NC3=CC(Cl)=C(F)C=C3)C2=C1)/C=C/CN4CCCCC4

LVXJQMNHJWSHET-AATRIKPKSA-N

EGFR

,

ERBB2

,

ERBB4

Yes

Yes

No

Yes