1. Chemogenomics
2. KDR

KDR

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

3791

6307

P35968

VGFR2_HUMAN

Vascular endothelial growth factor receptor 2

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000660aPO4

Motesanib

O=C(NC1=CC=C(C(C)(C)CN2)C2=C1)C3=C(NCC4=CC=NC=C4)N=CC=C3.OP(O)(O)=O.OP(O)(O)=O

ONDPWWDPQDCQNJ-UHFFFAOYSA-N

CSF1R

,

FLT1

,

FLT4

,

KDR

,

KIT

,

PDGFRA

,

PDGFRB

,

RET

,

ZAP70

Yes

Yes

No

Yes

EUB0000661a

Tivozanib

COC1=C(OC)C=C(C(OC2=CC(Cl)=C(NC(NC3=NOC(C)=C3)=O)C=C2)=CC=N4)C4=C1.O

VTWZGSZTIGEYIC-UHFFFAOYSA-N

FLT1

,

FLT4

,

KDR

Yes

Yes

Yes

Yes