1. Chemogenomics
2. MAP2K1

MAP2K1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

5604

6840

Q02750

MP2K1_HUMAN

Dual specificity mitogen-activated protein kinase kinase 1

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000129b

Selumetinib

CN(C=N1)C2=C1C(F)=C(NC3=CC=C(Br)C=C3Cl)C(C(NOCCO)=O)=C2

CYOHGALHFOKKQC-UHFFFAOYSA-N

MAP2K1

,

MAP2K2

Yes

Yes

No

Yes

EUB0000599a

CI-1040

C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl

GFMMXOIFOQCCGU-UHFFFAOYSA-N

MAP2K1

,

MAP2K2

Yes

Yes

No

Yes

EUB0000666a

PD0325901

FC1=C(F)C(NC2=CC=C(I)C=C2F)=C(C(NOC[C@H](O)CO)=O)C=C1

SUDAHWBOROXANE-SECBINFHSA-N

MAP2K1

,

MAP2K2

Yes

Yes

No

Yes

EUB0000684a

cobimetinib

FC1=C(NC2=CC=C(I)C=C2F)C(C(N3CC([C@@H]4CCCCN4)(O)C3)=O)=CC=C1F

BSMCAPRUBJMWDF-KRWDZBQOSA-N

MAP2K1

Yes

Yes

No

Yes