1. Chemogenomics
2. MET

MET

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

4233

7029

P08581

MET_HUMAN

Hepatocyte growth factor receptor

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000293b

BAY-474

CC1=C(C#N)C(c2ccc3[nH]nc(C)c3c2)C(C#N)=C(C)N1

QKVFMAAIXZONRN-UHFFFAOYSA-N

MET

Yes

Yes

No

Yes

EUB0000590a

SU11274

ClC1=CC(N(C)S(C2=CC=C(NC(/C3=C\C4=C(C)C(C(N5CCN(C)CC5)=O)=C(C)N4)=O)C3=C2)(=O)=O)=CC=C1

FPYJSJDOHRDAMT-KQWNVCNZSA-N

MET

Yes

Yes

Yes

Yes

EUB0000619a

PF-04217903

OCCN(N=C1)C=C1C2=CN=C3C(N(CC4=CC=C5C(C=CC=N5)=C4)N=N3)=N2

PDMUGYOXRHVNMO-UHFFFAOYSA-N

MET

Yes

Yes

No

Yes

EUB0000624a

BMS 777607

CCOC1=C(C(=O)N(C=C1)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F

VNBRGSXVFBYQNN-UHFFFAOYSA-N

AXL

,

MET

,

MST1R

,

TYRO3

Yes

Yes

No

No