1. Chemogenomics
  2. OPRK1

OPRK1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family
4986
8154
P41145
OPRK_HUMAN
opioid receptor kappa 1
GPCR

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available
EUB0000365aCl
BRL-52537
Chemical structure of compound BRL-52537
ClC1=CC=C(CC(=O)N2CCCCC2CN2CCCC2)C=C1Cl
NGVLSOWJSUUYDE-RSAXXLAASA-N
Agonist
OPRK1
Yes
Yes
No
Yes
EUB0000372aCl
NORBINALTORPHIMINE
Chemical structure of compound NORBINALTORPHIMINE
OC1=C2O[C@H]3C4=C(C[C@@]5(O)[C@H]6CC(C=C1)=C2[C@@]35CCN6CC1CC1)C1=C(N4)[C@@H]2OC3=C(O)C=CC4=C3[C@@]22CCN(CC3CC3)[C@H](C4)[C@]2(O)C1
SQNOQAMOMUBPHK-FFZCCNEYSA-N
Antagonist
OPRK1
Yes
Yes
Yes
Yes
EUB0000390aCl
ICI-204448
Chemical structure of compound ICI-204448
CN(C(CN1CCCC1)C1=CC(OCC(O)=O)=CC=C1)C(=O)CC1=CC=C(Cl)C(Cl)=C1
FNDGLVOYAQNQPE-UHFFFAOYSA-N
Agonist
OPRK1
Yes
Yes
No
Yes
EUB0000536a
LEU-ENKEPHALIN
Chemical structure of compound LEU-ENKEPHALIN
CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC1=CC=C(O)C=C1)C(O)=O
URLZCHNOLZSCCA-VABKMULXSA-N
Agonist
OPRD1
,
OPRK1
,
OPRM1
Yes
Yes
Yes
Yes