1. Chemogenomics
2. OPRM1

OPRM1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

4988

8156

P35372

OPRM_HUMAN

opioid receptor mu 1

GPCR

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000427aCl

JTC-801

CCC1=CC=C(OCC2=CC=CC=C2C(=O)NC2=CC3=C(N)C=C(C)N=C3C=C2)C=C1

NQLIYKXNAXKMBL-UHFFFAOYSA-N

Antagonist

OPRL1

,

OPRM1

Yes

Yes

Yes

Yes

EUB0000447aCl

LOPERAMIDE

CN(C)C(=O)C(CCN1CCC(O)(CC1)C1=CC=C(Cl)C=C1)(C1=CC=CC=C1)C1=CC=CC=C1

PGYPOBZJRVSMDS-UHFFFAOYSA-N

Agonist

OPRM1

Yes

Yes

Yes

Yes

EUB0000536a

LEU-ENKEPHALIN

CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC1=CC=C(O)C=C1)C(O)=O

URLZCHNOLZSCCA-VABKMULXSA-N

Agonist

OPRD1

,

OPRK1

,

OPRM1

Yes

Yes

Yes

Yes